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Financial Management Skills in Aging, MCI and Dementia: Cross Sectional Relationship to 18F-Florbetapir PET Cortical β-amyloid Deposition

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The Journal of Prevention of Alzheimer's Disease Aims and scope Submit manuscript

Abstract

Background

There is a need to more fully characterize financial capacity losses in the preclinical and prodromal stages of Alzheimer’s disease (AD) and their pathological substrates.

Objectives

To test the association between financial skills and cortical β-amyloid deposition in aging and subjects at risk for AD.

Design

Cross-sectional analyses of data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI-3) study conducted across 50 plus sites in the US and Canada.

Setting

Multicenter biomarker study.

Participants

243 subjects (144 cognitively normal, 79 mild cognitive impairment [MCI], 20 mild AD).

Measurements

18F-Florbetapir brain PET scans to measure global cortical β-amyloid deposition (SUVr) and the Financial Capacity Instrument Short Form (FCI-SF) to evaluate an individual’s financial skills in monetary calculation, financial concepts, checkbook/register usage, and bank statement usage. There are five sub scores and a total score (range of 0–74) with higher scores indicating better financial skill.

Results

FCI-SF total score was significantly worse in MCI [Cohen’s d= 0.9 (95%CI: 0.6–1.2)] and AD subjects [Cohen’s d=3.1(CI: 2.5–3.7)] compared to normals. Domain scores and completion times also showed significant difference. Across all subjects, higher cortical β-amyloid SUVr was significantly associated with worse FCI-SF total score after co-varying for age, education, and cognitive score [Cohen’s f2=0.751(CI: 0.5–1.1)]. In cognitively normal subjects, after covarying for age, gender, and education, higher β -amyloid PET SUVr was associated with longer task completion time [Cohen’s f2=0.198(CI: 0.06–0.37)].

Conclusion

Using a multicenter study sample, we document that financial capacity is impaired in the prodromal and mild stages of AD and that such impairments are, in part, associated with the extent of cortical β-amyloid deposition. In normal aging, β-amyloid deposition is associated with slowing of financial tasks. These data confirm and extend prior research highlighting the utility of financial capacity assessments in at risk samples.

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Acknowledgments

We are grateful to Dr. Daniel Marson for his valuable insights. Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (adni.loni.ucla.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wpcontent/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf

Funding

Funding: Funding for data collection were funded by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904, Michael Weiner, PI) and DOD ADNI (Department of Defense award number W81XWH-12-2-0012). ADNI is funded by the National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering, and through contributions from the following: AbbVie, Alzheimer’s Association; Alzheimer’s Drug Discovery Foundation; Araclon Biotech; BioClinica, Inc.; Biogen; Bristol-Myers Squibb Company; CereSpir, Inc.; Cogstate; Eisai Inc.; Elan Pharmaceuticals, Inc.; Eli Lilly and Company; EuroImmun; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; Fujirebio; GE Healthcare; IXICO Ltd.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research & Development LLC.; Lumosity; Lundbeck; Merck & Co., Inc.; Meso Scale Diagnostics, LLC.; NeuroRx Research; Neurotrack Technologies; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Piramal Imaging; Servier; Takeda Pharmaceutical Company; and Transition Therapeutics. The Canadian Institutes of Health Research is providing funds to support ADNI clinical sites in Canada. Private sector contributions are facilitated by the Foundation for the National Institutes of Health (http://www.fnih.org). The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer’s Therapeutic Research Institute at the University of Southern California. ADNI data are disseminated by the Laboratory for Neuro Imaging at the University of Southern California.

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Authors and Affiliations

  1. Departments of Psychiatry, Medicine and Radiology, Duke University Health System; Departments of Radiology and Biomedical Imaging, Medicine, Psychiatry, and Neurology, University of California, San Francisco, USA

    Sierra Tolbert, Y. Liu, C. Hellegers, J. R. Petrella, M. W. Weiner, T. Z. Wong & P. Murali Doraiswamy

  2. DUMC Box #3018, Durham, NC, 27710, USA

    Sierra Tolbert

Authors
  1. Sierra Tolbert
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  2. Y. Liu
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  7. P. Murali Doraiswamy
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ADNI Study Group

Corresponding author

Correspondence to Sierra Tolbert.

Ethics declarations

Competing Financial Interests: MWW is the principal investigator for ADNI and all other authors are ADNI investigators at Duke. PMD is supported by NIH, DOD and Cure Alzheimer’s Fund, has served as an advisor to and/or received grants from several companies and non-profits in this field, and owns stock in or serves on boards of companies whose products are not discussed here. Other co-authors may also have received grants or advisory fees from companies for other projects.

Ethical standards: The institutional review board at Duke University Health System and at each ADNI site reviewed and approved the ADNI protocol. All subjects and their legal representatives, where appropriate, gave written informed consent prior to data collection.

Conflict of interest: We reported this under the existing para titled Competing Financial Interests.

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Tolbert, S., Liu, Y., Hellegers, C. et al. Financial Management Skills in Aging, MCI and Dementia: Cross Sectional Relationship to 18F-Florbetapir PET Cortical β-amyloid Deposition. J Prev Alzheimers Dis 6, 274–282 (2019). https://doi.org/10.14283/jpad.2019.26

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