Ursula A. Matulonis, MD

Ursula A. Matulonis, MD

Medical Oncology

Contact Information

Office Phone Number

617-632-2334

Fax

617-632-3479

Appointments

617-632-2175

Biography

Ursula A. Matulonis, MD

Ursula A. Matulonis, MD is Chief of the Division of Gynecologic Oncology at the Dana-Farber Cancer Institute and Professor of Medicine at Harvard Medical School. She is the first recipient of the Brock-Wilson Family Chair at the Dana-Farber Cancer Institute. She co-leads the Gynecologic Cancer Program within the Dana-Farber/Harvard Cancer Center and the Ovarian Cancer Specialized Program in Research Excellence (SPORE) grant from the National Cancer Institute. Her research focuses on developing new targeted therapies for gynecologic malignancies, with a specific interest in ovarian cancer and endometrial cancer.

Dr. Matulonis has led several PARP inhibitor, anti-angiogenic agent, immunotherapy, and combination trials for ovarian cancer in the United States and internationally. Dr. Matulonis serves on the Massachusetts Ovarian Cancer Task Force, chairs the Gyn subcommittee of the Alliance cooperative group, and the Scientific Advisory Board for the Ovarian Cancer Research Alliance, the Rivkin Foundation, the Clearity Foundation, and Overcome. She has received the Dana-Farber Dennis Thompson Compassionate Care Scholar award, the Lee M. Nadler "Extra Mile" Award, the Clearity Foundation award, the Zakim Award at Dana-Farber for patient advocacy, and recently in 2020, the Albany Medical College Alumni Association Distinguished Alumna Award. She has been named one of Boston's Best Physicians in Medical Oncology by Boston Magazine numerous times. Dr. Matulonis is also a recipient of grant funding from the Breast Cancer Research Foundation examining differences between ovarian cancer, endometrial cancer and breast cancer.

After receiving her MD from Albany Medical College, she completed an internship and residency at the University of Pittsburgh, followed by a medical oncology fellowship at Dana-Farber Cancer Institute in Boston, MA.

Researcher

Physician

Chief, Division of Gynecologic Oncology
Brock-Wilson Family Chair
Institute Physician
Professor of Medicine, Harvard Medical School

Centers/Programs

Clinical Interests

Gynecologic malignancies, New therapies for gynecologic cancers

Board Certification

  • Internal Medicine, 2000
  • Medical Oncology, 2003

Fellowship

  • Dana-Farber Cancer Institute, Medical Oncology

Residency

  • University of Pittsburgh, Internal Medicine

Medical School

  • Albany Medical College

Recent Awards

  • Partners in Excellence Award, Partners Health Care 2010
  • Lee Nadler "Extra Mile" Award 2009
  • "Boston Magazine" Best Doctors 2009
  • Partners in Excellence Award, Partners Health Care 2000
  • Dennis Thompson Compassionate Care Scholar, Brigham and Women's Hospital 2000

Research

    Clinical Trials in Gynecologic Malignancies

    The Medical Gynecologic Oncology Program serves as the infrastructure for clinical and translational research at Dana-Farber Cancer Institute. Our research involves testing novel drugs and biologics in newly diagnosed as well as recurrent gynecologic tumors: ovarian, endometrial, cervical, vaginal, and vulvar cancers. A list of ongoing clinical trials is available via our website. Our integrated team of medical oncologists, gynecologic oncology surgeons, radiation oncologists, gynecologic oncology pathologists, clinical research team, and basic science researchers is immersed in a number of translational projects. Examples of ongoing projects in 2010 include the expression profiling and genotyping of ovarian cancer, the study of circulating tumor cells in ovarian cancer, investigation of HER3 expression and signalling and therapeutic potential of HER3, and the study of the PI3 kinase pathway in endometrial cancer.

    Publications

      • Phase 1/2 study of combined BCL-xL and MEK inhibition with navitoclax and trametinib in KRAS or NRAS mutant advanced solid tumors. Clin Cancer Res. 2024 Mar 08. View in: Pubmed

      • Phase 1b study of mirvetuximab soravtansine, a folate receptor alpha (FRa)-targeting antibody-drug conjugate, in combination with carboplatin and bevacizumab in patients with platinum-sensitive ovarian cancer. Gynecol Oncol. 2024 Mar 05; 185:186-193. View in: Pubmed

      • Combined aromatase, CDK4/6 and PI3K blockade using letrozole/abemaciclib/LY3023414 in endometrial cancer. Gynecol Oncol Rep. 2024 Apr; 52:101348. View in: Pubmed

      • Phenotypes of Hypersensitivity Reactions to Pegylated Liposomal Doxorubicin: Safety and Efficacy of 128 rapid Desensitizations. J Allergy Clin Immunol Pract. 2024 Feb 17. View in: Pubmed

      • Benchmarking mismatch repair testing for patients with cancer receiving immunotherapy. Cancer Cell. 2024 Feb 12; 42(2):323. View in: Pubmed

      • Poor Concordance Between Cancer Antigen-125 and RECIST Assessment for Progression in Patients With Platinum-Sensitive Relapsed Ovarian Cancer on Maintenance Therapy With a Poly(ADP-ribose) Polymerase Inhibitor. J Clin Oncol. 2024 Jan 12; JCO2301182. View in: Pubmed

      • Benchmarking mismatch repair testing for patients with cancer receiving immunotherapy. Cancer Cell. 2024 01 08; 42(1):6-7. View in: Pubmed

      • Experiences of patients with peritoneal carcinomatosis-related complex care needs and their caregivers. Gynecol Oncol. 2024 Feb; 181:68-75. View in: Pubmed

      • Mirvetuximab soravtansine-gynx: first antibody/antigen-drug conjugate (ADC) in advanced or recurrent ovarian cancer. Int J Gynecol Cancer. 2023 Dec 14. View in: Pubmed

      • Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker. Cancer Discov. 2023 12 12; 13(12):2532-2547. View in: Pubmed

      • FF-10850, a Novel Liposomal Topotecan Achieves Superior Antitumor Activity via Macrophage- and Ammonia-Mediated Payload Release in the Tumor Microenvironment. Mol Cancer Ther. 2023 Dec 01; 22(12):1454-1464. View in: Pubmed

      • Open-Source, Step-Counting Algorithm for Smartphone Data Collected in Clinical and Nonclinical Settings: Algorithm Development and Validation Study. JMIR Cancer. 2023 Nov 15; 9:e47646. View in: Pubmed

      • Transforming ovarian cancer care by targeting minimal residual disease. Med. 2023 11 10; 4(11):755-760. View in: Pubmed

      • Molecular determinants of clinical outcomes of pembrolizumab in recurrent ovarian cancer: Exploratory analysis of KEYNOTE-100. Gynecol Oncol. 2023 Nov; 178:119-129. View in: Pubmed

      • Pilot randomized trial of an acceptance-based telehealth intervention for women with ovarian cancer and PARP inhibitor-related fatigue. Gynecol Oncol. 2023 10; 177:165-172. View in: Pubmed

      • Clinical and translational advances in ovarian cancer therapy. Nat Cancer. 2023 09; 4(9):1239-1257. View in: Pubmed

      • Reply to Z.R. McCaw et al. J Clin Oncol. 2023 Oct 10; 41(29):4705-4706. View in: Pubmed

      • Mirvetuximab soravtansine for platinum-resistant epithelial ovarian cancer. Expert Rev Anticancer Ther. 2023 Jul-Dec; 23(8):783-796. View in: Pubmed

      • Relacorilant + Nab-Paclitaxel in Patients With Recurrent, Platinum-Resistant Ovarian Cancer: A Three-Arm, Randomized, Controlled, Open-Label Phase II Study. J Clin Oncol. 2023 10 20; 41(30):4779-4789. View in: Pubmed

      • Safety and management of niraparib monotherapy in ovarian cancer clinical trials. Int J Gynecol Cancer. 2023 06 05; 33(6):971-981. View in: Pubmed

      • DKK1 is a predictive biomarker for response to DKN-01: Results of a phase 2 basket study in women with recurrent endometrial carcinoma. Gynecol Oncol. 2023 05; 172:82-91. View in: Pubmed

      • Validation of an open-source smartphone step counting algorithm in clinical and non-clinical settings. medRxiv. 2023 Mar 28. View in: Pubmed

      • Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. bioRxiv. 2023 Mar 17. View in: Pubmed

      • Phase II Trials of Iniparib (BSI-201) in Combination with Gemcitabine and Carboplatin in Patients with Recurrent Ovarian Cancer. Oncologist. 2023 03 17; 28(3):252-257. View in: Pubmed

      • Strategies for prevention and management of ocular events occurring with mirvetuximab soravtansine. Gynecol Oncol Rep. 2023 Jun; 47:101155. View in: Pubmed

      • Molecular Landscape of Mullerian Clear Cell Carcinomas Identifies The Cancer Genome Atlas-like Prognostic Subgroups. Mod Pathol. 2023 05; 36(5):100123. View in: Pubmed

      • Society of Gynecologic Oncology Journal Club: Controversial conversations in Gynecologic cancer - The ABCs of ADCs (Antibody drug Conjugates). Gynecol Oncol Rep. 2023 Feb; 45:101141. View in: Pubmed

      • Safety and efficacy of mirvetuximab soravtansine, a folate receptor alpha (FRa)-targeting antibody-drug conjugate (ADC), in combination with bevacizumab in patients with platinum-resistant ovarian cancer. Gynecol Oncol. 2023 03; 170:241-247. View in: Pubmed

      • Efficacy and Safety of Mirvetuximab Soravtansine in Patients With Platinum-Resistant Ovarian Cancer With High Folate Receptor Alpha Expression: Results From the SORAYA Study. J Clin Oncol. 2023 05 01; 41(13):2436-2445. View in: Pubmed

      • STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer. J Immunother Cancer. 2023 01; 11(1). View in: Pubmed

      • The rapid evolution of PARP inhibitor therapy for advanced ovarian cancer: Lessons being learned and new questions emerging from phase 3 trial long-term outcome data. Gynecol Oncol. 2022 Dec; 167(3):401-403. View in: Pubmed

      • Ad hoc Analysis of the Phase III ENGOT-OV16/NOVA Study: Niraparib Efficacy in Germline BRCA Wild-type Recurrent Ovarian Cancer with Homologous Recombination Repair Defects. Cancer Res Commun. 2022 11; 2(11):1436-1444. View in: Pubmed

      • A randomized phase II trial of bevacizumab vs. bevacizumab and erlotinib as first-line consolidation after carboplatin, paclitaxel, and bevacizumab in newly diagnosed patients with mullerian tumors. Int J Clin Oncol. 2022 Dec; 27(12):1881-1890. View in: Pubmed

      • Mutational Signature 3 Detected from Clinical Panel Sequencing is Associated with Responses to Olaparib in Breast and Ovarian Cancers. Clin Cancer Res. 2022 11 01; 28(21):4714-4723. View in: Pubmed

      • A Phase II, Two-Stage Study of Letrozole and Abemaciclib in Estrogen Receptor-Positive Recurrent Endometrial Cancer. J Clin Oncol. 2023 01 20; 41(3):599-608. View in: Pubmed

      • EPIK-O/ENGOT-OV61: Alpelisib plus olaparib vs cytotoxic chemotherapy in high-grade serous ovarian cancer (phase III study). Future Oncol. 2022 Sep 06. View in: Pubmed

      • Evaluation of Treatment With Talazoparib and Avelumab in Patients With Recurrent Mismatch Repair Proficient Endometrial Cancer. JAMA Oncol. 2022 09 01; 8(9):1317-1322. View in: Pubmed

      • Satellite repeat RNA expression in epithelial ovarian cancer associates with a tumor-immunosuppressive phenotype. J Clin Invest. 2022 08 15; 132(16). View in: Pubmed

      • Improved T-cell Immunity Following Neoadjuvant Chemotherapy in Ovarian Cancer. Clin Cancer Res. 2022 08 02; 28(15):3356-3366. View in: Pubmed

      • Niraparib treatment for patients with BRCA-mutated ovarian cancer: review of clinical data and therapeutic context. Future Oncol. 2022 Jul; 18(23):2505-2536. View in: Pubmed

      • Pre-diagnosis and post-diagnosis dietary patterns and survival in women with ovarian cancer. Br J Cancer. 2022 10; 127(6):1097-1105. View in: Pubmed

      • STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer. Nat Commun. 2022 05 31; 13(1):3022. View in: Pubmed

      • Phase 1b Clinical Trial with Alpelisib plus Olaparib for Patients with Advanced Triple-Negative Breast Cancer. Clin Cancer Res. 2022 04 14; 28(8):1493-1499. View in: Pubmed

      • Immunotherapy for ovarian cancer. Clin Adv Hematol Oncol. 2022 Apr; 20(4):240-253. View in: Pubmed

      • A phase II study of MK-2206, an AKT inhibitor, in uterine serous carcinoma. Gynecol Oncol Rep. 2022 Apr; 40:100974. View in: Pubmed

      • Olaparib With or Without Cediranib Versus Platinum-Based Chemotherapy in Recurrent Platinum-Sensitive Ovarian Cancer (NRG-GY004): A Randomized, Open-Label, Phase III Trial. J Clin Oncol. 2022 07 01; 40(19):2138-2147. View in: Pubmed

      • Patient reported outcomes for cisplatin and radiation followed by carboplatin/paclitaxel versus carboplatin/paclitaxel for locally advanced endometrial carcinoma: An NRG oncology study. Gynecol Oncol. 2022 02; 164(2):428-436. View in: Pubmed

      • Combined PARP and HSP90 inhibition: preclinical and Phase 1 evaluation in patients with advanced solid tumours. Br J Cancer. 2022 04; 126(7):1027-1036. View in: Pubmed

      • Predicting master transcription factors from pan-cancer expression data. Sci Adv. 2021 Nov 26; 7(48):eabf6123. View in: Pubmed

      • MicroRNA profiling in a case-control study of African American women with uterine serous carcinoma. Gynecol Oncol. 2021 12; 163(3):453-458. View in: Pubmed

      • A Replication stress biomarker is associated with response to gemcitabine versus combined gemcitabine and ATR inhibitor therapy in ovarian cancer. Nat Commun. 2021 09 22; 12(1):5574. View in: Pubmed

      • Checkpoint Blockade: Not Yet NINJA Status in Ovarian Cancer. J Clin Oncol. 2021 11 20; 39(33):3651-3655. View in: Pubmed

      • Prognostic nomogram for progression-free survival in patients with BRCA mutations and platinum-sensitive recurrent ovarian cancer on maintenance olaparib therapy following response to chemotherapy. Eur J Cancer. 2021 09; 154:190-200. View in: Pubmed

      • Sequential Phase II clinical trials evaluating CRLX101 as monotherapy and in combination with bevacizumab in recurrent ovarian cancer. Gynecol Oncol. 2021 09; 162(3):661-666. View in: Pubmed

      • Enhanced Efficacy of Aurora Kinase Inhibitors in G2/M Checkpoint Deficient TP53 Mutant Uterine Carcinomas Is Linked to the Summation of LKB1-AKT-p53 Interactions. Cancers (Basel). 2021 May 03; 13(9). View in: Pubmed

      • Molecular and clinical predictors of improvement in progression-free survival with maintenance PARP inhibitor therapy in women with platinum-sensitive, recurrent ovarian cancer: A meta-analysis. Cancer. 2021 07 15; 127(14):2432-2441. View in: Pubmed

      • Incidence of myelodysplastic syndrome and acute myeloid leukemia in patients receiving poly-ADP ribose polymerase inhibitors for the treatment of solid tumors: A meta-analysis of randomized trials. Gynecol Oncol. 2021 06; 161(3):653-659. View in: Pubmed

      • Phase II Study of the WEE1 Inhibitor Adavosertib in Recurrent Uterine Serous Carcinoma. J Clin Oncol. 2021 05 10; 39(14):1531-1539. View in: Pubmed

      • Disease Distribution at Presentation Impacts Benefit of IP Chemotherapy Among Patients with Advanced-Stage Ovarian Cancer. Ann Surg Oncol. 2021 Oct; 28(11):6705-6713. View in: Pubmed

      • Stepping into survivorship pilot study: Harnessing mobile health and principles of behavioral economics to increase physical activity in ovarian cancer survivors. Gynecol Oncol. 2021 05; 161(2):581-586. View in: Pubmed

      • Case Report: Frontoparietal Metastasis From a Primary Fallopian Tube Carcinoma. Front Surg. 2021; 8:594570. View in: Pubmed

      • Embedding a genetic counselor into oncology clinics improves testing rates and timeliness for women with ovarian cancer. Gynecol Oncol. 2021 02; 160(2):457-463. View in: Pubmed

      • Enhanced Efficacy of Simultaneous PD-1 and PD-L1 Immune Checkpoint Blockade in High-Grade Serous Ovarian Cancer. Cancer Res. 2021 01 01; 81(1):158-173. View in: Pubmed

      • Detection of ERBB2 amplification in uterine serous carcinoma by next-generation sequencing: an approach highly concordant with standard assays. Mod Pathol. 2021 03; 34(3):603-612. View in: Pubmed

      • Clinical assays for assessment of homologous recombination DNA repair deficiency. Gynecol Oncol. 2020 12; 159(3):887-898. View in: Pubmed

      • Long-term safety in patients with recurrent ovarian cancer treated with niraparib versus placebo: Results from the phase III ENGOT-OV16/NOVA trial. Gynecol Oncol. 2020 11; 159(2):442-448. View in: Pubmed

      • Homologous recombination deficiency real-time clinical assays, ready or not? Gynecol Oncol. 2020 12; 159(3):877-886. View in: Pubmed

      • Deciphering serous ovarian carcinoma histopathology and platinum response by convolutional neural networks. BMC Med. 2020 08 18; 18(1):236. View in: Pubmed

      • Combined pembrolizumab and pegylated liposomal doxorubicin in platinum resistant ovarian cancer: A phase 2 clinical trial. Gynecol Oncol. 2020 10; 159(1):72-78. View in: Pubmed

      • Mural nodules in mucinous ovarian tumors represent a morphologic spectrum of clonal neoplasms: a morphologic, immunohistochemical, and molecular analysis of 13 cases. Mod Pathol. 2021 03; 34(3):613-626. View in: Pubmed

      • Author Correction: A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors. Nat Med. 2020 Aug; 26(8):1307. View in: Pubmed

      • PARP Inhibitor Resistance Mechanisms and Implications for Post-Progression Combination Therapies. Cancers (Basel). 2020 Jul 25; 12(8). View in: Pubmed

      • Combined CDK4/6 and PD-1 Inhibition in Refractory SMARCA4-Deficient Small-Cell Carcinoma of the Ovary, Hypercalcemic Type. JCO Precis Oncol. 2020; 4:736-742. View in: Pubmed

      • A single-cell landscape of high-grade serous ovarian cancer. Nat Med. 2020 08; 26(8):1271-1279. View in: Pubmed

      • Emerging drugs for the treatment of ovarian cancer: a focused review of PARP inhibitors. Expert Opin Emerg Drugs. 2020 06; 25(2):165-188. View in: Pubmed

      • Berzosertib plus gemcitabine versus gemcitabine alone in platinum-resistant high-grade serous ovarian cancer: a multicentre, open-label, randomised, phase 2 trial. Lancet Oncol. 2020 07; 21(7):957-968. View in: Pubmed

      • Differential blood count as triage tool in evaluation of pelvic masses. Int J Gynecol Cancer. 2021 05; 31(5):733-743. View in: Pubmed

      • Author Correction: Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer. Nat Commun. 2020 05 18; 11(1):2543. View in: Pubmed

      • A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors. Nat Med. 2020 05; 26(5):792-802. View in: Pubmed

      • Genomic Determinants of De Novo Resistance to Immune Checkpoint Blockade in Mismatch Repair-Deficient Endometrial Cancer. JCO Precis Oncol. 2020; 4:492-497. View in: Pubmed

      • COVID-19 and ovarian cancer: Exploring alternatives to intravenous (IV) therapies. Gynecol Oncol. 2020 07; 158(1):34-36. View in: Pubmed

      • Author Correction: Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer. Nat Commun. 2020 Apr 17; 11(1):1940. View in: Pubmed

      • Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer. Nat Commun. 2020 03 19; 11(1):1459. View in: Pubmed

      • An immune-centric exploration of BRCA1 and BRCA2 germline mutation related breast and ovarian cancers. BMC Cancer. 2020 Mar 12; 20(1):197. View in: Pubmed

      • Reversion and non-reversion mechanisms of resistance to PARP inhibitor or platinum chemotherapy in BRCA1/2-mutant metastatic breast cancer. Ann Oncol. 2020 05; 31(5):590-598. View in: Pubmed

      • Phase Ib study of mirvetuximab soravtansine, a folate receptor alpha (FRa)-targeting antibody-drug conjugate (ADC), in combination with bevacizumab in patients with platinum-resistant ovarian cancer. Gynecol Oncol. 2020 05; 157(2):379-385. View in: Pubmed

      • Results of an abbreviated phase II study of AKT inhibitor MK-2206 in the treatment of recurrent platinum-resistant high grade serous ovarian, fallopian tube, or primary peritoneal carcinoma (NCT 01283035). Gynecol Oncol Rep. 2020 May; 32:100546. View in: Pubmed

      • Phase II, 2-stage, 2-arm, PIK3CA mutation stratified trial of MK-2206 in recurrent endometrial cancer. Int J Cancer. 2020 07 15; 147(2):413-422. View in: Pubmed

      • A Randomized Phase II Trial of Epigenetic Priming with Guadecitabine and Carboplatin in Platinum-resistant, Recurrent Ovarian Cancer. Clin Cancer Res. 2020 03 01; 26(5):1009-1016. View in: Pubmed

      • Overall survival and updated progression-free survival outcomes in a randomized phase II study of combination cediranib and olaparib versus olaparib in relapsed platinum-sensitive ovarian cancer. Ann Oncol. 2019 Apr; 30(4):551-557. View in: Pubmed

      • Correction to: "Safety and dose modification for patients receiving niraparib". Ann Oncol. 2019 May; 30(5):859. View in: Pubmed

      • Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study. Ann Oncol. 2019 Jul; 30(7):1080-1087. View in: Pubmed

      • Prediagnosis and postdiagnosis smoking and survival following diagnosis with ovarian cancer. Int J Cancer. 2020 08 01; 147(3):736-746. View in: Pubmed

      • Assessment of Combined Nivolumab and Bevacizumab in Relapsed Ovarian Cancer: A Phase 2 Clinical Trial. JAMA Oncol. 2019 12 01; 5(12):1731-1738. View in: Pubmed

      • Transcriptome analysis reveals overlap in fusion genes in a phase I clinical cohort of TNBC and HGSOC patients treated with buparlisib and olaparib. J Cancer Res Clin Oncol. 2020 Feb; 146(2):503-514. View in: Pubmed

      • Choosing wisely: Selecting PARP inhibitor combinations to promote anti-tumor immune responses beyond BRCA mutations. Gynecol Oncol. 2020 02; 156(2):488-497. View in: Pubmed

      • Niraparib Maintenance Treatment Improves Time Without Symptoms or Toxicity (TWiST) Versus Routine Surveillance in Recurrent Ovarian Cancer: A TWiST Analysis of the ENGOT-OV16/NOVA Trial. J Clin Oncol. 2019 12 01; 37(34):3183-3191. View in: Pubmed

      • Phase II Study of Avelumab in Patients With Mismatch Repair Deficient and Mismatch Repair Proficient Recurrent/Persistent Endometrial Cancer. J Clin Oncol. 2019 10 20; 37(30):2786-2794. View in: Pubmed

      • Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer. Mol Cancer Res. 2019 11; 17(11):2281-2293. View in: Pubmed

      • The CHK1 Inhibitor Prexasertib Exhibits Monotherapy Activity in High-Grade Serous Ovarian Cancer Models and Sensitizes to PARP Inhibition. Clin Cancer Res. 2019 10 15; 25(20):6127-6140. View in: Pubmed

      • Results of an abbreviated Phase Ib study of the HDAC6 inhibitor ricolinostat and paclitaxel in recurrent ovarian, fallopian tube, or primary peritoneal cancer. Gynecol Oncol Rep. 2019 Aug; 29:118-122. View in: Pubmed

      • Patients with BRCA mutated ovarian cancer may have fewer circulating MDSC and more peripheral CD8+ T cells compared with women with BRCA wild-type disease during the early disease course. Oncol Lett. 2019 Oct; 18(4):3914-3924. View in: Pubmed

      • Single-Arm Phases 1 and 2 Trial of Niraparib in Combination With Pembrolizumab in Patients With Recurrent Platinum-Resistant Ovarian Carcinoma. JAMA Oncol. 2019 Aug 01; 5(8):1141-1149. View in: Pubmed

      • Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study. Ann Oncol. 2019 07 01; 30(7):1080-1087. View in: Pubmed

      • Outcomes of secondary cytoreductive surgery for patients with platinum-sensitive recurrent ovarian cancer. Am J Obstet Gynecol. 2019 12; 221(6):625.e1-625.e14. View in: Pubmed

      • Adjuvant Chemotherapy plus Radiation for Locally Advanced Endometrial Cancer. N Engl J Med. 2019 06 13; 380(24):2317-2326. View in: Pubmed

      • Niraparib Maintenance Therapy in Patients With Recurrent Ovarian Cancer After a Partial Response to the Last Platinum-Based Chemotherapy in the ENGOT-OV16/NOVA Trial. J Clin Oncol. 2019 11 10; 37(32):2968-2973. View in: Pubmed

      • Results from a single arm, single stage phase II trial of trametinib and GSK2141795 in persistent or recurrent cervical cancer. Gynecol Oncol. 2019 07; 154(1):95-101. View in: Pubmed

      • Safety and dose modification for patients receiving niraparib. Ann Oncol. 2019 05 01; 30(5):859. View in: Pubmed

      • Assessment of a Chemotherapy Response Score (CRS) System for Tubo-Ovarian High-Grade Serous Carcinoma (HGSC). Int J Gynecol Pathol. 2019 May; 38(3):230-240. View in: Pubmed

      • Immunotherapy and radiation combinatorial trials in gynecologic cancer: A potential synergy? Gynecol Oncol. 2019 07; 154(1):236-245. View in: Pubmed

      • Niraparib monotherapy for late-line treatment of ovarian cancer (QUADRA): a multicentre, open-label, single-arm, phase 2 trial. Lancet Oncol. 2019 05; 20(5):636-648. View in: Pubmed

      • Overall survival and updated progression-free survival outcomes in a randomized phase II study of combination cediranib and olaparib versus olaparib in relapsed platinum-sensitive ovarian cancer. Ann Oncol. 2019 04 01; 30(4):551-557. View in: Pubmed

      • Diagnosis and management of a recurrent polymerase-epsilon (POLE)-mutated endometrial cancer. Gynecol Oncol. 2019 06; 153(3):471-478. View in: Pubmed

      • Olaparib and a-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial. Lancet Oncol. 2019 04; 20(4):570-580. View in: Pubmed

      • Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference. Cancer. 2019 06 15; 125(12):1963-1972. View in: Pubmed

      • Final report on serial phase II trials of all-intraperitoneal chemotherapy with or without bevacizumab for women with newly diagnosed, optimally cytoreduced carcinoma of Müllerian origin. Gynecol Oncol. 2019 05; 153(2):223-229. View in: Pubmed

      • POLE-mutated clear cell cervical cancer associated with in-utero diethylstilbestrol exposure. Gynecol Oncol Rep. 2019 May; 28:15-17. View in: Pubmed

      • Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness. Mol Cancer Ther. 2019 03; 18(3):642-655. View in: Pubmed

      • Efficacy and safety of niraparib as maintenance treatment in older patients (=?70?years) with recurrent ovarian cancer: Results from the ENGOT-OV16/NOVA trial. Gynecol Oncol. 2019 03; 152(3):560-567. View in: Pubmed

      • Alisertib in Combination With Weekly Paclitaxel in Patients With Advanced Breast Cancer or Recurrent Ovarian Cancer: A Randomized Clinical Trial. JAMA Oncol. 2019 01 01; 5(1):e183773. View in: Pubmed

      • A randomized phase II study of cabozantinib versus weekly paclitaxel in the treatment of persistent or recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer: An NRG Oncology/Gynecologic Oncology Group study. Gynecol Oncol. 2019 03; 152(3):548-553. View in: Pubmed

      • PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer. Cell Rep. 2018 12 11; 25(11):2972-2980.e5. View in: Pubmed

      • Targeting DNA Damage Response and Repair as a Therapeutic Strategy for Ovarian Cancer. Hematol Oncol Clin North Am. 2018 12; 32(6):997-1010. View in: Pubmed

      • Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13. Elife. 2018 11 13; 7. View in: Pubmed

      • Evaluation of Prophylactic Corticosteroid Eye Drop Use in the Management of Corneal Abnormalities Induced by the Antibody-Drug Conjugate Mirvetuximab Soravtansine. Clin Cancer Res. 2019 03 15; 25(6):1727-1736. View in: Pubmed

      • Targeted Next-Generation Sequencing Reveals Clinically Actionable BRAF and ESR1 Mutations in Low-Grade Serous Ovarian Carcinoma. JCO Precis Oncol. 2018; 2018. View in: Pubmed

      • Long-term efficacy, tolerability and overall survival in patients with platinum-sensitive, recurrent high-grade serous ovarian cancer treated with maintenance olaparib capsules following response to chemotherapy. Br J Cancer. 2018 10; 119(9):1075-1085. View in: Pubmed

      • Ovarian Cancer. Hematol Oncol Clin North Am. 2018 12; 32(6):xiii-xiv. View in: Pubmed

      • Multiple Myeloma Masquerading as Ovarian Carcinosarcoma Metastases: A Case Report and Review of the Approach to Multiple Myeloma Screening and Diagnosis. Case Rep Hematol. 2018; 2018:3029650. View in: Pubmed

      • Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids. Cancer Discov. 2018 11; 8(11):1404-1421. View in: Pubmed

      • BRAF and AXL oncogenes drive RIPK3 expression loss in cancer. PLoS Biol. 2018 08; 16(8):e2005756. View in: Pubmed

      • Safety and dose modification for patients receiving niraparib. Ann Oncol. 2018 08 01; 29(8):1784-1792. View in: Pubmed

      • Pre-diagnosis and post-diagnosis use of common analgesics and ovarian cancer prognosis (NHS/NHSII): a cohort study. Lancet Oncol. 2018 08; 19(8):1107-1116. View in: Pubmed

      • Quality of life in patients with recurrent ovarian cancer treated with niraparib versus placebo (ENGOT-OV16/NOVA): results from a double-blind, phase 3, randomised controlled trial. Lancet Oncol. 2018 08; 19(8):1117-1125. View in: Pubmed

      • Durable response in a woman with recurrent low-grade endometrioid endometrial cancer and a germline BRCA2 mutation treated with a PARP inhibitor. Gynecol Oncol. 2018 08; 150(2):219-226. View in: Pubmed

      • PARP Inhibitors in Ovarian Cancer: A Trailblazing and Transformative Journey. Clin Cancer Res. 2018 09 01; 24(17):4062-4065. View in: Pubmed

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      • Combination carboplatin and pemetrexed for the treatment of platinum-sensitive recurrent ovarian cancer. J Clin Oncol 26. 2008; May 20 suppl(abstr 5523). View in: Pubmed

      • Phase II study of carboplatin and paclitaxel in elderly women with newly diagnosed ovarian, peritoneal, or fallopian tube cancer. J Clin Oncol 26. 2008; May 20 suppl(abstr 5590). View in: Pubmed

      • Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer. J Clin Oncol. 2007 Nov 20; 25(33):5180-6. View in: Pubmed

      • PHASE 3 STUDY: CANFOSFAMIDE (C, TLK286) PLUS CARBOPLATIN (P) VS LIPOSOMAL DOXORUBICIN (D) AS 2ND LINE THERAPY OF PLATINUM (PL) RESISTANT OVARIAN CANCER (OC) . International Journal of Gynecologic Oncology. 2007. View in: Pubmed

      • PHASE II STUDY OF CARBOPLATIN AND PEMETREXED FOR THE TREATMENT OF PLATINUM-SENSITIVE RECURRENT OVARIAN CANCER . International Journal of Gynecologic Cancer. 2007. View in: Pubmed

      • RESULTS FROM A PHASE II RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND TRIAL SUGGEST IMPROVED PFS WITH THE ADDITION OF PERTUZUMAB TO GEMCITABINE IN PATIENTS WITH PLATINUM-RESISTANT OVARIAN, FALLOPIAN TUBE, OR PRIMARY PERITONEAL CANCER . International Journal of Gynecologic Oncology. 2007. View in: Pubmed

      • PHASE I TRIAL OF LIPOSOMAL DOXORUBICIN AND ZD1839 IN PATIENTS WITH REFRACTORY GYNECOLOGICAL MALIGNANCIES OR METASTATIC BREAST CANCER . International Journal Gynecologic Oncology. 2007. View in: Pubmed

      • Long term impact of chemotherapy in early stage ovarian cancer survivors. . Submitted to Gyn Oncology. 2007. View in: Pubmed

      • Chemotherapy and radiation therapy in UPSC. Journal of Clinical Oncology 2007 ASCO Annual Meeting Proceedings Part I. Vol 25, No. 1. 2007; Vol 25, No. 18S (June 20 Suppl(abstract 5535). View in: Pubmed

      • Randomized trial of acupuncture versus sham control for prevention of myelosuppression in patients with gynecologic malignancies. Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. 2007; Vol 25, No. 18S (June 20 Suppl(abstract 19524). View in: Pubmed

      • Results of all-intraperitoneal carboplatin and paclitaxel regimen shows good tolerability and efficacy for advanced ovarian cancer. Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. 2007; Vol 25, No. 18S (June 20 Suppl(abstract 5521). View in: Pubmed

      • Results from a phase II randomized, placebo-controlled, double-blind trial suggest improved PFS with the addition of pertuzumab to gemcitabine in patients with platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer. Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. 2007; Vol 25, No. 18S (June 20 Suppl(abstract 5507). View in: Pubmed

      • Acupuncture for chemotherapy-induced leukopenia: exploratory meta-analysis of randomized controlled trials. J Soc Integr Oncol. 2007; 5(1):1-10. View in: Pubmed

      • Protein expression and clinical features of ovarian cancer in the elderly. Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. 2007; Vol 25, No. 18S (June 20 Suppl(Abstract 5574). View in: Pubmed

      • Results of all-intraperitoneal carboplatin and paclitaxel regimen shows good tolerability and efficacy for advanced ovarian cancer. Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. 2007; Vol 25, No. 18S (June 20 Suppl(abstract 5521). View in: Pubmed

      • ErbB3 protein expression in serous ovarian carcinomas of elderly women. Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings. 2007; Part I. Vol 25, No. 18S (June (abstract 16026). View in: Pubmed

      • Safety of maintenance bevacizumab after first-line chemotherapy for advanced ovarian and müllerian cancers. Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. 2007; Vol 25, No. 18S (June 20 Suppl(abstract 5517). View in: Pubmed

      • Integrated report of the phase 2 experience with XL999 administered IV to patients (pts) with NSCLC, renal cell CA (RCC), metastatic colorectal CA (CRC), recurrent ovarian CA, acute myelogenous leaukemia (AML), and multiple myeloma (MM). Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. 2007; Vol 25, No. 18S (June 20 Suppl(Abstract 3591). View in: Pubmed

      • A phase II trial of EMD72000 (matuzumab), a humanized anti-EGFR monoclonal antibody, in patients with platinum-resistant ovarian and primary peritoneal malignancies. Gynecol Oncol. 2007 Mar; 104(3):727-31. View in: Pubmed

      • Ovarian cancer. Clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2006 Oct; 4(9):912-39. View in: Pubmed

      • Rational use of cytotoxic chemotherapy for recurrent ovarian cancer. J Natl Compr Canc Netw. 2006 Oct; 4(9):947-53. View in: Pubmed

      • Clinical activity of pertuzumab (rhuMAb 2C4), a HER dimerization inhibitor, in advanced ovarian cancer: potential predictive relationship with tumor HER2 activation status. J Clin Oncol. 2006 Sep 10; 24(26):4324-32. View in: Pubmed

      • Three sequential chemotherapy doublets for the treatment of newly diagnosed advanced müllerian malignancies: the modified triple doublet regimen. Gynecol Oncol. 2006 Nov; 103(2):575-80. View in: Pubmed

      • Phase I trial of liposomal doxorubicin and ZD 1839 in patients with refractory gynecological malignancies or metastatic breast cancer. J Clin Oncol. 2006 Jun 20; 24(18_suppl):5085. View in: Pubmed

      • A randomized phase II trial with gemcitabine with or without pertuzumab (rhuMAb 2C4) in platinum-resistant ovarian cancer (OC): Preliminary safety data. J Clin Oncol. 2006 Jun 20; 24(18_suppl):13001. View in: Pubmed

      • Pharmacokinetic analysis of an all intraperitoneal carboplatin and paclitaxel regimen in ovarian cancer patients demonstrates favorable systemic bioavailability of both agents. J Clin Oncol. 2006 Jun 20; 24(18_suppl):5008. View in: Pubmed

      • Long-term impact of chemotherapy on early stage ovarian cancer patients. J Clin Oncol. 2006 Jun 20; 24(18_suppl):5024. View in: Pubmed

      • Phase II trial of GM-CSF in women with asymptomatic müllerian cancer. J Clin Oncol. 2006 Jun 20; 24(18_suppl):5081. View in: Pubmed

      • Evaluation of serial serum IL-6 levels in women with newly diagnosed ovarian cancer on a prospective clinical trial. J Clin Oncol. 2006 Jun 20; 24(18_suppl):5065. View in: Pubmed

      • Phase II study of carboplatin, paclitaxel and bevacizumab as first line chemotherapy and consolidation for advanced müllerian tumors. J Clin Oncol. 2006 Jun 20; 24(18_suppl):5020. View in: Pubmed

      • Bevacizumab in patients with advanced platinum-resistant ovarian cancer. J Clin Oncol. 2006 Jun 20; 24(18_suppl):5006. View in: Pubmed

      • Negative laparoscopy is highly predictive of negative second-look laparotomy following chemotherapy for ovarian, tubal, and primary peritoneal carcinoma. Gynecol Oncol. 2006 Nov; 103(2):570-4. View in: Pubmed

      • Phase I/II dose finding study of combination cisplatin and gemcitabine in patients with recurrent cervix cancer. Gynecol Oncol. 2006 Oct; 103(1):160-4. View in: Pubmed

      • Evaluation of serial serum IL-6 levels in women with newly diagnosed ovarian cancer on a prospective clinical trial. Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Part I. 2006; Vol 24, No. 18S (June 20 Suppl(abstract 5065). View in: Pubmed

      • Long-term impact of chemotherapy on early stage ovarian cancer patients. Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Part I. 2006; Vol 24, No. 18S (June 20 Suppl(abstract 5024). View in: Pubmed

      • Pharmacokinetic analysis of an all intraperitoneal carboplatin and paclitaxel regimen in ovarian cancer patients demonstrates favorable systemic bioavailability of both agents. Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Part I. 2006; Vol 24, No. 18S (June 20 Suppl(abstract 5008). View in: Pubmed

      • Phase I/II Dose finding study of combination cisplatin and gemcitabine in patients with recurrent cervix cancer . SGO. 2006; (abstract 161). View in: Pubmed

      • A randomized phase II trial with gemcitabine with or without pertuzumab (rhuMAb 2C4) in platinum-resistant ovarian cancer (OC): preliminary safety data. Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Part I. 2006; Vol 24, No. 18S (June 20 Suppl(abstract 13001). View in: Pubmed

      • Phase I trial of liposomal doxorubicin and ZD 1839 in patients with refractory gynecological malignancies or metastatic breast cancer. Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Part I. 2006; Vol 24, No. 18S (June 20 Suppl(abstract 5085). View in: Pubmed

      • Phase II study of carboplatin, paclitaxel and bevacizumab as first line chemotherapy and consolidation for advanced müllerian tumors. Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Part I. 2006; Vol 24, No. 18S (June 20 Suppl(abstract 5020). View in: Pubmed

      • Clinical Activity of Single Agent Pertuzumab (rhuMab 2C4), a HER Dimerization Inhibitor, in Advanced Ovarian Cancer (OC): Potential Predictive Relationship with Tumor HER2 Activation Status. . SGO. 2006; 20(abstract 20). View in: Pubmed

      • Bevacizumab in patients with advanced platinum-resistant ovarian cancer. Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Part I. 2006; Vol 24, No. 18S (June 20 Suppl(abstract 5006). View in: Pubmed

      • End of life Care. Muss, Johnson, and Hunter (eds.): Multidisciplinary Treatment and Management of Cancer in the Elderly . 2006. View in: Pubmed

      • Phase I trial of liposomal doxorubicin and ZD 1839 in patients with refractory gynecological malignancies or metastatic breast cancer. Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Part I. 2006; Vol 24, No. 18S (June 20 Suppl(abstract 5085). View in: Pubmed

      • Phase II trial of GM-CSF in women with asymptomatic müllerian cancer. Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Part I. 2006; Vol 24, No. 18S (June 20 Suppl(abstract 5081). View in: Pubmed

      • Long-acting octreotide for the treatment and symptomatic relief of bowel obstruction in advanced ovarian cancer. J Pain Symptom Manage. 2005 Dec; 30(6):563-9. View in: Pubmed

      • A phase II study of irofulven in women with recurrent and heavily pretreated ovarian cancer. Gynecol Oncol. 2006 Apr; 101(1):55-61. View in: Pubmed

      • A phase II study of fixed dose rate gemcitabine in patients with relapsed müllerian tumors. Int J Gynecol Cancer. 2005 Nov-Dec; 15(6):1035-41. View in: Pubmed

      • Metaplastic carcinoma of the breast with neuroglial differentiation. Breast. 2006 Aug; 15(4):545-9. View in: Pubmed

      • Å6, a urokinase plasminogen activator (uPA)-derived peptide in patients with advanced gynecologic cancer: A phase I trial . Å6, a urokinase plasminogen activator (uPA)-derived peptide in patients with advanced gynecologic cancer: A phase I trial. 2005; 99(1):50-57. View in: Pubmed

      • A6, a urokinase plasminogen activator (uPA)-derived peptide in patients with advanced gynecologic cancer: a phase I trial. Gynecol Oncol. 2005 Oct; 99(1):50-7. View in: Pubmed

      • Rapid inpatient/outpatient desensitization for chemotherapy hypersensitivity: standard protocol effective in 57 patients for 255 courses. Gynecol Oncol. 2005 Nov; 99(2):393-9. View in: Pubmed

      • A phase I clinical trial of continual alternating etoposide and topotecan in refractory solid tumours. Br J Cancer. 2005 Jul 11; 93(1):54-9. View in: Pubmed

      • Unexpected association between induction of immunity to the universal tumor antigen CYP1B1 and response to next therapy. Clin Cancer Res. 2005 Jun 15; 11(12):4430-6. View in: Pubmed

      • Rapid inpatient and outpatient desensitization for carboplatin or paclitaxel hypersensitivity: A protocol effective in patients with gynecologic malignancies. J Clin Oncol. 2005 Jun; 23(16_suppl):5090. View in: Pubmed

      • A phase II Trial of EMD72000 (matuzumab), a humanized anti-EGFR monoclonal antibody in subjects with heavily treated and platinum-resistant advanced Müllerian malignancies. J Clin Oncol. 2005 Jun; 23(16_suppl):3151. View in: Pubmed

      • Long-acting octreotide for the treatment of symptoms of bowel obstruction in advanced ovarian cancer. J Clin Oncol. 2005 Jun; 23(16_suppl):5159. View in: Pubmed

      • A phase II trial of modified triple doublets for the treatment of advanced Müllerian malignancies. J Clin Oncol. 2005 Jun; 23(16_suppl):5010. View in: Pubmed

      • Phase II trial of anastrazole in combination with gefitinib in women with asymptomatic mullerian cancer. J Clin Oncol. 2005 Jun; 23(16_suppl):5063. View in: Pubmed

      • Cancer of the ovary. N Engl J Med. 2005 Mar 24; 352(12):1268-9; author reply 1268-9. View in: Pubmed

      • Rapid desensitization for hypersensitivity reactions to paclitaxel and docetaxel: a new standard protocol used in 77 successful treatments. Gynecol Oncol. 2005 Mar; 96(3):824-9. View in: Pubmed

      • Long-acting octreotide (Sandostatin LAR®Depot) for the treatment of symptoms of bowel obstruction in advanced ovarian cancer. Journal of Clinical Oncology, 2005 ASCO Annual Meeting Proceedings. 2005; Vol 23, No. 16S, Part I of II (abstract 5159). View in: Pubmed

      • Clinical activity of pertuzumab (rhuMab 2C4) in advanced, refractory or recurrent ovarian cancer (OC), and the role of HER2 activation status. Journal of Clinical Oncology, 2005 ASCO Annual Meeting Proceedings. 2005; Vol 23, No. 16S, Part I of II (abstract 5051). View in: Pubmed

      • A Phase II Trial of EMD72000 (matuzumab), a humanized anti-EGFR monoclonal antibody in subjects with heavily treated and platinum-resistant advanced Müllerian malignancies. Journal of Clinical Oncology, 2005 ASCO Annual Meeting Proceedings. 2005; Vol 23, No. 16S, Part I of II (abstract 3151). View in: Pubmed

      • Phase II Trial of Anastrazole in Combination with Gefitinib in Women with Asymptomatic Mullerian Cancer. Journal of Clinical Oncology, 2005 ASCO Annual Meeting Proceedings. 2005; Vol 23, No. 16S, Part I of II (abstract 5063). View in: Pubmed

      • A phase II trial of modified triple doublets for the treatment of advanced Müllerian malignancies. Journal of Clinical Oncology, 2005 ASCO Annual Meeting Proceedings. 2005; Vol 23, No. 16S, Part I of II (abstract 5010). View in: Pubmed

      • Rapid inpatient and outpatient desensitization for carboplatin or paclitaxel hypersensitivity: a protocol effective in patients with gynecologic malignancies. Journal of Clinical Oncology, 2005 ASCO Annual Meeting Proceedings. 2005; Vol 23, No. 16S, Part I of II (abstract 5090). View in: Pubmed

      • A pilot trial of TAC (paclitaxel, doxorubicin, and carboplatin) chemotherapy with filgastrim (r-metHuG-CSF) support followed by radiotherapy in patients with "high-risk" endometrial cancer. Gynecol Oncol. 2005 Jan; 96(1):198-203. View in: Pubmed

      • Rapid inpatient and outpatient desensitization for carboplatin or paclitaxel hypersensitivity: a protocol effective in patients with gynecologic malignancies. Journal of Clinical Oncology, 2005 ASCO Annual Meeting Proceedings. 2005; Vol 23, No. 16S, Part I of II (abstract 5090). View in: Pubmed

      • A phase II trial of weekly docetaxel in patients with platinum-resistant epithelial ovarian, primary peritoneal serous cancer, or fallopian tube cancer . Gynecologic Onlology. 2004; 95(3):624-631. View in: Pubmed

      • A phase II trial of weekly docetaxel in patients with platinum-resistant epithelial ovarian, primary peritoneal serous cancer, or fallopian tube cancer. Gynecol Oncol. 2004 Dec; 95(3):624-31. View in: Pubmed

      • Ovarian cancer clinical practice guidelines. J Natl Compr Canc Netw. 2004 Nov; 2(6):526-47. View in: Pubmed

      • Carboplatin hypersensitivity: a 6-h 12-step protocol effective in 35 desensitizations in patients with gynecological malignancies and mast cell/IgE-mediated reactions. Gynecol Oncol. 2004 Nov; 95(2):370-6. View in: Pubmed

      • Efficacy of epoetin alfa in a retrospective non-stratified subgroup analysis of a breast cancer cohort receiving non-platinum chemotherapy. Tumori. 2004 Sep-Oct; 90(5):449-57. View in: Pubmed

      • Attitudes to chemotherapy in patients with ovarian cancer. Gynecol Oncol. 2004 Aug; 94(2):427-35. View in: Pubmed

      • A phase II study of fixed dose-rate gemcitabine in patients with relapsed Müllerian tumors. J Clin Oncol. 2004 Jul 15; 22(14_suppl):5151. View in: Pubmed

      • Long-acting octreotide for the treatment of symptoms of bowel obstruction and intermittent obstruction in advanced ovarian cancer. J Clin Oncol. 2004 Jul 15; 22(14_suppl):5148. View in: Pubmed

      • Phase I trial of escalating doses of topotecan in combination with a fixed dose of pegylated liposomal doxorubicin in women with müllerian malignancies. Gynecol Oncol. 2004 Jun; 93(3):702-7. View in: Pubmed

      • Phase II and pharmacokinetic study of ecteinascidin 743 in patients with progressive sarcomas of soft tissues refractory to chemotherapy. J Clin Oncol. 2004 Apr 15; 22(8):1480-90. View in: Pubmed

      • End of life issues in older patients. Semin Oncol. 2004 Apr; 31(2):274-81. View in: Pubmed

      • A phase II study of liposomal lurtotecan (OSI-211) in patients with topotecan resistant ovarian cancer. Gynecol Oncol. 2004 Apr; 93(1):229-32. View in: Pubmed

      • A phase II study of fixed dose-rate gemcitabine in patients with relapsed Müllerian tumors. Journal of Clinical Oncology, 2004 ASCO Annual Meeting Proceedings (Post-Meeting Edition). 2004; Vol 22, No 14S (July 15 Supple(abstract 5151). View in: Pubmed

      • Long-acting octreotide for the treatment of symptoms of bowel obstruction and intermittent obstruction in advanced ovarian cancer. Journal of Clinical Oncology, 2004 ASCO Annual Meeting Proceedings (Post-Meeting Edition). 2004; Vol 22, No 14S (July 15 Supple(abstract 5148). View in: Pubmed

      • Phase II trial of anastrozole in women with asymptomatic müllerian cancer. Gynecol Oncol. 2003 Dec; 91(3):596-602. View in: Pubmed

      • A phase II trial of three sequential doublets for the treatment of advanced müllerian malignancies. Gynecol Oncol. 2003 Nov; 91(2):293-8. View in: Pubmed

      • Phase II study of liposomal doxorubicin and weekly paclitaxel for recurrent Müllerian tumors. Gynecol Oncol. 2003 Sep; 90(3):610-8. View in: Pubmed

      • Attitudes to chemotherapy in patients with ovarian cancer. Proc Am Soc Clin Oncol. 2003; 22(abstract abstr 1888). View in: Pubmed

      • Phase I study of cisplatin and gemcitabine for recurrent cervix cancer following primary radiotherapy or newly diagnosed metastatic cervix cancer. Proc Am Soc Clin Oncol. 2003; 22(abstr 1872). View in: Pubmed

      • Gynecologic Cancers. Atlas of Diagnostic Oncology, Arthur Skarin, editor. 2003. View in: Pubmed

      • Significance of Positive Peritoneal Cytology in Women with Endometrial Cancer. ACS Endometrial Cancer. 2003. View in: Pubmed

      • A phase II study of the MDR inhibitor biricodar (INCEL, VX-710) and paclitaxel in women with advanced ovarian cancer refractory to paclitaxel therapy. Gynecol Oncol. 2002 Sep; 86(3):302-10. View in: Pubmed

      • Breast cancer screening in women previously treated for Hodgkin's disease: a prospective cohort study. J Clin Oncol. 2002 Apr 15; 20(8):2085-91. View in: Pubmed

      • A phase I study of vaccination with lethally irradiated, autologous ovarian cancer cells engineered by adenoviral mediated gene transfer to secrete human granulocyte-macrophage colony stimulating factor (GVAX). Proc Am Soc Clin Oncol. 2002; 21(abstr 1840). View in: Pubmed

      • A Phase I trial of continual sequential oral etoposide and infusional topotecan. Proc Am Soc Clin Oncol. 2002; 21(abstr 2168). View in: Pubmed

      • A Phase I-II study of 96-hour infusional topotecan and paclitaxel for patients with recurrent Müllerian tumors. Cancer. 2001 Sep 01; 92(5):1156-67. View in: Pubmed

      • Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer. J Clin Oncol. 2001 May 15; 19(10):2722-30. View in: Pubmed

      • The clinical utility of liposomal doxorubicin in recurrent ovarian cancer. Gynecol Oncol. 2001 May; 81(2):206-12. View in: Pubmed

      • A Phase II and Pharmacokinetic/Dynamic Study of Doxil and Weekly Paclitaxel Chemotherapy for Recurrent Müllerian Tumors. Proc Am Soc Clin Oncol. 2001; 20(abstr 2524). View in: Pubmed

      • Triple Doublet Chemotherapy for the Treatment of Mullerian Malignancies. Proc Am Soc Clin Oncol. 2001; 20(abstr 846). View in: Pubmed

      • Phase I trial of carboplatin, paclitaxel, etoposide, and cyclophosphamide with granulocyte colony stimulating factor as first-line therapy for patients with advanced epithelial ovarian cancer. Gynecol Oncol. 2000 May; 77(2):271-7. View in: Pubmed

      • Docetaxel administered on a weekly basis for metastatic breast cancer. J Clin Oncol. 2000 Mar; 18(6):1212-9. View in: Pubmed

      • Herceptin and Vinorelbine for HER2-Positive Metastatic Breast Cancer: A Phase II Study. Proc Am Soc Clin Oncol. 2000; 19(abstr 392). View in: Pubmed

      • Phase I Study of Cisplatin and Gemcitabine for Recurrent Cervix Cancer Following Primary Radiotherapy. Proc Am Soc Clin Oncol. 2000; 19(abstr 1571). View in: Pubmed

      • A Phase I Study of Cyclophosphamide, Doxorubicin, and Eniluracil/5-FU in Women with Advanced Breast Cancer: Preliminary Results. Proc Am Soc Clin Oncol. 2000; 19(abstr 444). View in: Pubmed

      • A Phase II and Pharmacokinetic/Dynamic Study of Doxil and Weekly Paclitaxel Chemotherapy for Recurrent Müllerian Tumors. Proc Am Soc Clin Oncol. 2000; 19(abstr 1623). View in: Pubmed

      • A Phase I/II and Pharmacokinetic Study of 96-Hour Infusional Topotecan and Paclitaxel Chemotherapy for Recurrent Müllerian Tumors. Proc Am Soc Clin Oncol. 2000; 19(abstr 1552). View in: Pubmed

      • Cytokines IL-1beta, IL-2, IL-6, IL-8, MCP-1, GM-CSF and TNFalpha in patients with epithelial ovarian cancer and their relationship to treatment with paclitaxel. Int J Gynecol Cancer. 2000 Jan; 10(1):33-41. View in: Pubmed

      • Phase I study of Doxil and vinorelbine in metastatic breast cancer. Ann Oncol. 1999 Sep; 10(9):1113-6. View in: Pubmed

      • A Phase I/II and Pharmacokinetic Study of 96 Hour Infusional Topotecan and Paclitaxel Chemotherapy for Relapsed Epithelial Ovarian Cancer. (Meeting abstract). 1999 ASCO Meeting. 1999; ASCO Meeting(abstract 1477). View in: Pubmed

      • A Phase I Study of Carboplatin, Taxol[Superscript TM], Etoposide, and Cyclophosphamide (CTEC) with Filgrastim as First-Line Therapy for Patients with Advanced Epithelial Ovarian Cancer (Meeting abstract). 1999 Asco Meeting. 1999; ASCO(abstract 1417). View in: Pubmed

      • A Retrospective Analysis of the Clinical Utility of Doxil in Recurrent Ovarian Cancer (ROC). (Meeting abstract). 1999 ASCO Meeting. 1999; ASCO Meeting(abstract 1434). View in: Pubmed

      • Breast Cancer: Modifiable Lifestyle Risk Factors, in Lifestyle Medicine. Editor: James M. Rippe. 1999. View in: Pubmed

      • Weekly Docetaxel (Taxotere[trade]) for Metastatic Breast Cancer: A Phase II Trial (Meeting abstract). 1999 ASCO Meeting. 1999; ASCO Meeting(abstract 484). View in: Pubmed

      • Inability to escalate vinorelbine dose intensity using a daily x3 schedule with and without filgrastim in patients with metastatic breast cancer. Cancer Chemother Pharmacol. 1999; 43(1):68-72. View in: Pubmed

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      • Breast cancer screening in young women who have been treated for Hodgkin's disease (Meeting abstract). 1996 ASCO Meeting. 1996; ASCO Meeting(abstract 1659). View in: Pubmed

      • Role of B7-1 in mediating an immune response to myeloid leukemia cells. Blood. 1995 May 01; 85(9):2507-15. View in: Pubmed

      • Factor independence of human myeloid leukemia cell lines is associated with increased phosphorylation of the proto-oncogene Raf-1. Exp Hematol. 1994 Oct; 22(11):1111-7. View in: Pubmed

      • Autologous peripheral stem cell transplantation of the blastic phase of chronic myeloid leukemia following sequential high-dose cytosine arabinoside and melphalan. Am J Hematol. 1994 Apr; 45(4):283-7. View in: Pubmed

      • Interleukin-3 and p210 BCR/ABL activate both unique and overlapping pathways of signal transduction in a factor-dependent myeloid cell line. Exp Hematol. 1993 Oct; 21(11):1460-6. View in: Pubmed

      • Prevention of Legionella infections in a bone marrow transplant unit: multifaceted approach to decontamination of a water system. Infect Control Hosp Epidemiol. 1993 Oct; 14(10):571-5. View in: Pubmed

      • Tyrosine phosphorylation of rasGAP and associated proteins in chronic myelogenous leukemia cell lines. Blood. 1992 May 01; 79(9):2215-20. View in: Pubmed

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      Dana-Farber Cancer Institute - Chestnut Hill

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