Arnoud Sonnenberg
Cell-matrix adhesion
Our group studies the molecular mechanisms that regulate the interaction of cells with components of the extracellular matrix. A major class of cell adhesion receptors are formed by members of the integrin family.
We would like to understand how integrins interact with their ligands and assemble multiprotein complexes at the cell-substratum site in normal and pathological conditions, define the interplay between integrins and growth factor receptors, and understand the underlying molecular mechanisms.