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Short Communication| Volume 6, ISSUE 6, P787-789, December 2020

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Prenatal cannabis exposure and sleep outcomes in children 9–10 years of age in the adolescent brain cognitive development SM study

  • Evan A. Winiger
    Correspondence
    Corresponding author: Evan A. Winiger, University of Colorado Boulder, Psychology and Neuroscience, Muenzinger Psychology Building,1905 Colorado Ave, Boulder CO 80309, United States.
    Affiliations
    Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA

    Department of Psychology and Neuroscience, University of Colorado Boulder. Muenzinger Psychology Building, Boulder, CO, USA
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  • John K Hewitt
    Affiliations
    Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA

    Department of Psychology and Neuroscience, University of Colorado Boulder. Muenzinger Psychology Building, Boulder, CO, USA
    Search for articles by this author

      Abstract

      Objectives

      Analyze the associations between prenatal cannabis exposure and child sleep outcomes.

      Methods

      Data from the Adolescent Brain Cognitive Development Study (ABCD Study®) was used to determine whether maternal reports of prenatal cannabis use were associated with child sleep outcomes among 11,875 children ages 9–10 controlling for covariates including prenatal substance exposure, mother's education, combined household income, parental marital status, race, child sex, and child age.

      Results

      Endorsement of any prenatal cannabis use was associated with symptoms of disorders of initiating and maintaining sleep, disorders of arousal, sleep wake disorders, disorders of excessive somnolence, and a summed sleep disorder score (all β > 0.10 and p < 0.03) while frequency of prenatal daily cannabis use was significantly associated with disorders of excessive somnolence (β = 0.29, p = 0.03).

      Conclusions

      Although causality is not established, the results suggest potential long-term effects of prenatal cannabis exposure on sleep and the prudence of abstinence from cannabis use while pregnant.

      Keywords

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      References

        • Agrawal A.
        • Rogers C.E.
        • Lessov-Schlaggar C.N.
        • Carter E.B.
        • Lenze S.N.
        • Grucza R.A.
        Alcohol, Cigarette, and Cannabis Use between 2002 and 2016 in Pregnant Women from a Nationally Representative Sample.
        JAMA Pediatr. 2019;
        • Bates D.
        • Mächler M.
        • Bolker B.M.
        • Walker S.C.
        Fitting linear mixed-effects models using lme4.
        J Stat Softw. 2015;
        • Berghuis P.
        • Rajnicek A.M.
        • Morozov Y.M.
        • et al.
        Hardwiring the bain: endocannabinoids shape neuronal connectivity.
        Science. 2007; 80
        • Bowles N.P.
        • Herzig M.X.
        • Shea S.A.
        Recent legalization of cannabis use: effects on sleep, health, and workplace safety.
        Nat Sci Sleep. 2017;
        • Bruni O.
        • Ottaviano S.
        • Guidetti V.
        • et al.
        The Sleep Disturbance Scale for Children (SDSC) construction and validation of an instrument to evaluate sleep disturbances in childhood and adolescence.
        J Sleep Res. 1996;
        • Dahl R.E.
        • Scher M.S.
        • Williamson D.E.
        • Robles N.
        • Day N.
        A Longitudinal Study of Prenatal Marijuana Use: effects on Sleep and Arousal at Age 3 Years.
        Arch Pediatr Adolesc Med. 1995;
        • Garavan H
        • Bartsch H.
        • Conway K.
        • Decastro A.
        • et al.
        Recruiting the ABCD sample: design considerations and procedures.
        Dev Cogn Neurosci. 2018 Aug; 32: 16-22https://doi.org/10.1016/j.dcn.2018.04.004
        • Hans S.L.
        Studies of prenatal exposure to drugs: focusing on parental care of children.
        Neurotoxicol. Teratol. 2002;
        • Harkany T.
        • Guzmán M.
        • Galve-Roperh I.
        • Berghuis P.
        • Devi L.A.
        • Mackie K.
        The emerging functions of endocannabinoid signaling during CNS development.
        Trends Pharmacol. Sci. 2007;
        • Scher M.S.
        • Richardson G.A.
        • Coble P.A.
        • Day N.L.
        • Stoffer D.S.
        The effects of prenatal alcohol and marijuana exposure: disturbances in neonatal sleep cycling and arousal.
        Pediatr. Res. 1988;
        • Tortoriello G.
        • Morris C.V.
        • Alpar A.
        • et al.
        Miswiring the brain: δ9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway.
        EMBO J. 2014;
        • Young-Wolff K.C.
        • Tucker L.Y.
        • Alexeeff S.
        • et al.
        Trends in self-reported and biochemically tested Marijuana use among pregnant females in California from 2009 to 2016.
        JAMA - J. Am. Med. Assoc. 2017;
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